Odd Side Effects: Who Knew???


Who isn’t groggy first thing in the morning? But nothing will snap you to attention faster than looking in the mirror and seeing a black tongue, or using the toilet only to notice that your urine has turned a colorful shade of blue, or that your stool is bright red or ghostly gray. Some everyday—and not so everyday—substances you ingest or have contact with can produce some pretty unusual side effects. Here are eight reactions that might surprise you.

1. Pepto-Bismol & Black Tongue/Stool

Used for indigestion, nausea, or diarrhea, this pink medication can make your tongue and stool turn charcoal black. This temporary and harmless effect occurs when bismuth (the active ingredient) interacts with hydrogen sulfide in your mouth and colon (large intestine). Brushing your teeth and tongue or rinsing your mouth right after taking each dose reduces the black-tongue effect. But depending on the time it takes for food to move through your colon, your stool can remain dark for several days after you stop the drug.

2. Beets & Red Urine

Eating beets can lend a brilliant crimson hue not just to your plate but also to your urine, thanks to the pigment betalain in this root vegetable. How red urine becomes may depend on such factors as your blood iron level and acids in food, such as ascorbic acid (vitamin C) or oxalic acid (as in spinach, Swiss chard, and many other foods). Genes may additionally play a role in “beeturia.” There are also reports of beets turning stool reddish.

3. Clam Chowder & Pale Poop

If your stools have taken on a ghostly gray or pale color, that bowl of New England clam chowder you ate the other day may be to blame, according to many anecdotal reports online. According to animal research, the titanium dioxide that is added to many meals, including canned chowders, to give them a white appearance, may be the cause of the colour shift. rather than gray. Food labels may list titanium dioxide, but more often they just say “artificial color.” Titanium dioxide in food is controversial due to unresolved safety concerns.

4. Drugs & Green/Blue Urine

Medications that can turn urine green include the antacid cimetidine (Tagamet), the anesthetic propofol (Diprivan), and the nonsteroidal anti-inflammatory drug indomethacin (Indocin). It may look alarming, but it’s harmless. Methylene blue, used in some diagnostic tests and to treat rare conditions such as methemoglobinemia (an inability of red blood cells to carry oxygen), can turn your urine blue—or, more typically, green, when the blue pigments in methylene blue combine with a compound that gives urine its normal yellow color.

5. Asparagus & Smelly Urine

Asparagus is notorious for making urine smell somewhat like rotten or boiled cabbage. It has long been debated whether only some people are capable of producing the odor, or whether all people make it but only some can smell it. A 2011 study confirmed that people differ both in their ability to produce the odor and in their ability to perceive it, due to genetic variations. A 2010 study in PLOS Genetics similarly found a genetic difference between people who can detect the odor and those who cannot.

6. Toothpaste & Gum Sloughing

There are numerous online comments from people who brushed with certain toothpastes and later noticed “stringy stuff” collecting along their gums. This tissue sloughing can occur if you are sensitive to some toothpaste ingredients—notably pyrophosphates in tartar-control products such as Crest Pro Health. If you’ve noticed this effect, switch to a non-tartar-control toothpaste without the offending ingredient. Sodium lauryl sulfate, a common foaming agent in toothpastes, has also been linked with tissue sloughing in some people.

7. Butternut Squash & Skin Peeling

Some people get itchy, blistered skin (contact dermatitis) when they peel and cut raw butternut or acorn squash. In a case reported in Contact Dermatitis in 1994, a woman who developed this allergic skin condition was treated with a prescription topical corticosteroid. The condition quickly resolved, only to recur several weeks later when she again peeled and cut squash. Triterpene compounds are thought to trigger the hypersensitivity. If you have had this reaction from butternut or acorn squash (or other produce), wear rubber or latex gloves when preparing them.

8. Cancer Drug & Fingerprints

Capecitabine is a chemo drug used to treat colon, breast, and other cancers. But it has a rare, and strange, side effect: loss of fingerprints. At first, researchers thought the fingerprints disappeared due to a blistering of the skin that can occur from the drug. But patients can develop the skin condition and not lose their fingerprints, and vice versa. Although it’s only temporary, it can compromise identification while it lasts. Patients going abroad should carry a doctor’s note indicating that they are taking this drug, since some countries require fingerprints upon entry and departure.

9. When to See a Doctor

If you experience color (or other) changes in your urine or stool, or have any other unusual bodily reactions such as strange rashes—and there is no obvious trigger—see your doctor to make sure it’s not something that needs evaluation and treatment. Black stool, for example, can be a warning sign of gastrointestinal bleeding. A blockage in the bile duct of the liver is one of several potentially dangerous diseases that can cause pale faeces. And green urine is sometimes not innocuous. It could, for instance, signal a urinary tract infection.

I'm Johan, a Freelance Content Creator & Content Writer from Bath, helping brands and businesses connect with their ideal clients.

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